Advisor - Medical Physics

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Position Summary

This role will support the application of nuclear medical physics in the research and development of imaging and therapeutic radiopharmaceuticals (RPT) in Oncology. The individual will work in a multidisciplinary environment and contribute from discovery through late-phase clinical research, with a strong emphasis on enabling preclinical and translational imaging and dosimetry capabilities that support clinical development.
The Advisor – Medical Physicist will provide hands-on technical expertise in SPECT image reconstruction (required), dosimetry analysis, scanner calibration, tool development, validation, QC workflows, and site qualification. This role will support the development of internal RLT analysis capabilities spanning discovery through clinical applications, enabling robust, scalable, and regulatory-aligned imaging and dosimetry workflows.

Responsibilities

• Lead development and validation of in-house RLT analysis tools, including image reconstruction, activity modeling, dosimetry calculation, and calibration methods in partnership with both the Discovery and Clinical teams

• Provide quantitative imaging and dosimetry to screen and rank candidate radioligands, informing candidate selection in partnership with the Discovery team

• Develop and implement imaging and dosimetry methodologies for preclinical RPT studies, including quantitative imaging and dose estimation in animal models, and translational dosimetry to estimate human dosimetry

• Own validation strategy and execution for internally developed tools, ensuring reproducibility and alignment with clinical and regulatory expectations

• Lead scanner qualification and performance characterization for preclinical and clinical PET and SPECT imaging systems in partnership with both the Discovery and Clinical teams

• Develop QC workflows and ensure consistent application across imaging reconstruction, dosimetry, and calibration outputs

• Perform internal dosimetry analyses across preclinical and clinical datasets and provide QC review of analysis outputs

• Identify and resolve technical bottlenecks in reconstruction, imaging, dosimetry, and QC workflows

• Support translation of preclinical imaging and dosimetry methods into early-phase clinical workflows

• Support development of SOPs, imaging manuals, dosimetry documentation, and regulatory deliverables

• Contribute to preparation of datasets, tables, figures, and analysis outputs supporting regulatory submissions

• Interface with IT and software engineering teams to implement, deploy, and maintain validated analysis platforms

• Support site qualification, troubleshooting, and routine data processing across studies

• Collaborate with cross-functional teams, external vendors, CROs, and imaging partners

• Ensure adherence to GCP, SOPs, and quality standards

Basic Requirements

• Advanced degree (PhD) in Medical Physics, Nuclear Physics, Biomedical Engineering or related field

Preferred Requirements

• Required: Expertise in SPECT image reconstruction and quantitative SPECT imaging

• Preferred: Experience with PET reconstruction and quantitative PET imaging

• Experience in radiopharmaceutical/internal dosimetry (organ level and/or voxel-based methods)

• Experience developing or validating scientific software or quantitative imaging workflows

• Strong understanding of nuclear imaging modalities (SPECT, PET, CT, MR)

• Ability to perform technical QC and communicate results to multidisciplinary teams

Work Environment

This position is Remote

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$151,500 - $244,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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