About the role:
We are seeking a highly motivated and intellectually agile Scientist to join our stealth-mode biotech company and contribute to programs focused on hematopoietic cell biology. This laboratory-based role will be responsible for designing, executing, and interpreting in vitro experiments that generate actionable insights and support scientific decision-making.
The successful candidate will be mechanistically minded, able to connect experimental observations to underlying biology, build novel reproducible assays, and deliver results in a fast-paced environment.
The position is a rare opportunity to play a pivotal role in the successful development of new drugs for patients within an early-stage therapeutics company backed by highly regarded investors.
Key Responsibilities:
- Lead efforts to develop a novel therapeutic for the treatment of a hematologic disease with unmet medical need
- Develop, optimize, and perform cell-based assays to evaluate the impact of compounds on:
- Erythroid differentiation (e.g., flow cytometry markers,morphology)
- Cell health (e.g., viability)
- Protein-level readouts (e.g., flow cytometry, ELISA, high content imaging, Western blot)
- RNA-level outcomes (e.g., qPCR)
- Culture and differentiate multiple cell lines using established and custom protocols.
- Collaborate with scientists, mentor and train associates in a small biotech startup environment.
- Translate and develop selected assays to support in vivo pharmacology studies.
- Maintain detailed laboratory records, perform data analysis, and present findings in team meetings.
- Ensure compliance with all lab safety, quality, and recordkeeping standards.
- Oversee research activities with external research organizations (CROs) as needed
Qualifications:
- PhD in Cell Biology, Molecular Biology, or a related field with 0-2 years of industry experience preferred
- BS or MS in Cell Biology, Molecular Biology, or a related field with 5+ years of relevant industry research experience will be considered
- Proven tissue culture experience with human cell lines and primary human cell culture—ideally CD34+ hematopoietic or other stem/progenitor cells. Familiarity with erythroid differentiation assays and hematopoietic biology is a plus.
- Molecular biology expertise including DNA and RNA purification and practical expertise with downstream nucleic acid-based (e.g., qPCR, and RNA-seq) and protein-based assays (e.g. flow cytometry, ELISA, and Western blotting)
- Demonstrated experience in building novel cell-based assays is a strong plus.
- Excellent attention to detail, organizational skills, and ability to work both independently and collaboratively.
- Excellent problem-solving skills and a track record of learning new techniques and scientific concepts quickly.
- Strong communication skills for cross-functional teamwork and clear documentation.
What we offer:
- Competitive compensation and benefits
- A collaborative, small-team environment with growth opportunities
- The opportunity to contribute to innovative drug discovery efforts and join an early-stage biotechnology company backed by highly regarded investors
Location: Cambridge, MA
