We are a fast-moving translational research lab driven by the need to develop curative, immune-based therapies for blood cancers such as chronic myeloid leukaemia (CML) and for Asian-specific solid tumours including nasopharyngeal cancer. A central pillar of our programme is harnessing natural killer (NK) cells as “off-the-shelf” cellular therapeutics that can eliminate malignant cells across both haematological and solid tumour settings. We combine leading-edge multi-omics single-cell profiling with AI/ML-guided discovery to define the mechanisms that govern NK cell fitness, persistence, and tumour recognition, then rigorously validate these findings using state-of-the-art platforms including NK cell in vitro expansion systems, engineered feeder and iPSC-based technologies, advanced functional assays, and in vivo tumour models. Our current work spans engineering and expanding NK cells for enhanced cytotoxicity and in vivo persistence, dissecting NK cell–tumour interactions within the immunosuppressive microenvironment of solid tumours, and deploying NK cell–based strategies to eliminate persistent leukaemia stem cells (LSCs) in minimal residual disease and prevent disease transformation. We seek a talented and driven post-doctoral Research Fellow to lead the design, expansion, and functional testing of NK cell products and to evaluate their anti-tumour activity in relevant pre-clinical models.
Key Responsibilities
We regret that only shortlisted candidates will be notified.
Location: Outram Campus
Organization: Duke-NUS Medical School
Department : Office of Research
Employee Referral Eligible: No
Job requisition ID : 34408
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The National University of Singapore is a leading global university known for its research and academic excellence.