Senior Project Manager, Enterprise PMO

Join Nemours Children’s Health

Nemours Children’s Health is seeking a strategic, highly collaborative Senior Project Manager to join our Enterprise Project Management Office. This is an exciting opportunity for an experienced project and program leader who thrives in complex environments, builds alignment across senior stakeholders, and brings structure, momentum, and clarity to initiatives that improve how we deliver care for children and families.

In this role, you will lead high-impact, system-wide projects that may span technology implementations, clinical workflow transformation, business operations, facilities and capital construction, infrastructure upgrades, and multi-vendor delivery models. You will partner with executive leaders and cross-functional teams to move priorities from strategy to execution while supporting Nemours’ mission to help create the healthiest generations of children.

Why This Role Matters

The Senior Project Manager serves as a trusted driver of enterprise change. You will help define scope, manage complex workstreams, anticipate risks, guide decision-making, and ensure initiatives are delivered with discipline, transparency, and measurable impact. Your work will directly support clinical, operational, technical, and facilities teams across a nationally recognized pediatric health system.

What You’ll Do

• Lead large-scale, enterprise-wide initiatives with significant strategic impact.
• Build integrated project and program structures across multiple objectives, dependencies, and workstreams.
• Partner with executive stakeholders to shape project scope, outcomes, governance, and strategic direction.
• Drive alignment across clinical, operational, technical, facilities, finance, and vendor teams.
• Lead organizational change management efforts that support adoption, readiness, and sustainable results.
• Use data, project health indicators, and risk insights to inform executive governance and prioritization decisions.
• Manage project budgets, procurement strategy, SOW development, vendor selection, and third-party partner performance.
• Support initiatives involving construction timelines, regulatory requirements, infrastructure needs, and operational readiness.
• Mentor and guide junior project managers while modeling PMO standards and continuous improvement.

What We’re Looking For

• Bachelor’s degree required; master’s degree preferred.
• 8+ years of project or program management experience, ideally in a complex healthcare, enterprise, technology, construction, or transformation environment.
• PMP or equivalent project management certification required.
• Demonstrated ability to influence executive stakeholders and lead through ambiguity.
• Strong experience managing risk, dependencies, budgets, governance forums, and cross-functional delivery teams.
• Experience with Epic, Oracle, mergers and acquisitions, capital projects, or infrastructure initiatives is highly valued.
• Exceptional communication, facilitation, analysis, problem-solving, and change leadership skills.

Why Nemours

At Nemours, you will be part of a mission-driven pediatric health system committed to going well beyond medicine. Our teams combine care, research, advocacy, education, prevention, and innovation to improve children’s health today and for generations to come. If you are a strategic project leader who can connect people, priorities, and execution in a highly complex environment, we invite you to bring your expertise to Nemours Children’s Health.

Apply Today

Lead complex, system-wide initiatives that help shape the future of pediatric care.

If you are ready to lead enterprise-wide initiatives that strengthen operations, advance innovation, and support exceptional pediatric care, we encourage you to apply for the Senior Project Manager, Enterprise PMO role at Nemours Children’s Health.