Senior Associate Scientist

Senior Associate Scientist - CELGJP00003972

18 months with a possibility to extend

Celgene – San Diego

Summary/Scope

The Protein Homeostasis Thematic Center of Excellence (PH TCOE) is seeking a highly motivated Senior Associate Scientist with experience in immunology-based assays to participate in drug discovery research with a particular focus on protein homeostasis as it applies to the Immune-Oncology field. The successful candidate will work collaboratively in a multi-disciplinary environment to design and execute in vitro studies to further our understanding of the immunomodulatory effects of our novel compounds. Responsibilities include the development of primary cell and cell-line based co-culture assays to support target validation, mechanism of action, and biomarker selection. The responsibilities further include the profiling of novel compounds in cell-based assays to drive biomarker identification for several research programs. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCOE functional areas and to present his or her work at project team meetings and to the senior research leadership.

Responsibilities (will include, but are not limited to):

- Plan and execute scientific experiments

- Analyze and interpret scientific data

- Maintain primary and cancer cell lines and conduct routine cell culture tasks

- Conduct various routine cell based assays to characterize drug compounds

- Accurately maintain written reports and organize data

- Present data in team meetings

- Review current literature pertaining to relevant projects

Skills/Knowledge Required:

1. Bachelor’s degree in a scientific discipline with at least 8 years industry experience or Master’s degree with at least 6 years industry experience..

2. Practical experience in, and a solid understanding of basic cell biology, immunology, and assay development.

3. Extensive experience with mammalian cell culture (primary cells and cell lines) using single cells and co-culture cell models. Experience using single compound treatment and combination treatment studies is essential.

4. Expertise with a variety of cell-based assay technologies including antibody-based detection methods (e.g. Western, ELISA, immunoprecipitation), cell imaging (immunofluorescence, Incucyte, Cellomics), cell phenotyping technologies (e.g., flow cytometry) and functional assays such as cell cycle and apoptosis

5. Experience with molecular biology techniques such as RNAi and/or CRISPR, RT-PCR, and lenti-viral work is a plus.

6. Experience with the use of HTP/HCS and automation instruments is a plus.

7. Excellent communication, presentation, collaboration and organizational skills are required as well as the ability to independently design, execute, and trouble-shoot experiments through completion.

8. Data analysis skills and experience with a variety of scientific software applications are required.

9. The successful candidate will be an ambitious self-starter, be motivated to apply his/her skills to meet diverse project needs, and enjoy working in a fast-paced dynamic team environment.

All your information will be kept confidential according to EEO guidelines.

IF THIS IS THE JOB OPPORTUNITY FOR YOU GIVE ME A CALL AT 619-727-5167 ASAP! I want to know more about your preferences.

If in case you know someone who might be interested for this, feel free to pass it along. I look forward to hearing from you!