The Hatley lab studies how normal development processes are perturbed to drive pediatric embryonal tumors using rhabdomyosarcoma as a model system. Our findings defined the cell of origin of rhabdomyosarcoma, a presumed skeletal muscle tumor, as an endothelial progenitor cell (Cancer Cell, 33:108-124, 2018 and Nature Communications, 14:729, 2023). We now seek to elucidate the mechanism of this cell reprogramming event and its role in cell transformation. The lab leverages genetically engineered mouse models, patient-derived xenografts, human and mouse tumor and primary cell lines as well as human induced pluripotent stem cells as model systems to interrogate the underlying pathobiology of pediatric rhabdomyosarcoma.
The Hatley lab is a very collaborative, interactive environment focused on scientific and career development of trainees. The lab supports a healthy work/life balance and diversity with a focus on career development. Four former postdocs are now tenure track Assistant Professors at academic institutions. Dr. Hatley was the 2019 mentor of the year at St. Jude. Successful applicants should have strong organizational and communication skills with drive and dedication to participate as a member of our team.
https://www.stjude.org/research/labs/hatley-lab.html
Minimum Experience:
The ideal candidate should have just received their PhD or have less than one year of postdoctoral research. Experience in mouse models, cell biology, and molecular biology is preferred. Please send a cover letter describing research interests and accomplishments, CV and the names and addresses of three references to [email protected].
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St. Jude Children's Research Hospital is a pediatric treatment and research facility focused on children's catastrophic diseases, particularly leukemia and other cancers.