Life Science Research Professional 1

The Mourrain Lab, within the Department of Psychiatry & Behavioral Sciences at Stanford University’s School of Medicine, is seeking a full time Life Science Research Professional 1 (LSRP 1) to study sleep and its effects on neurobiology. The Mourrain Lab specializes in neuroscience, genetics, epigenetics, developmental biology, and engineering to achieve the following objectives:

1. Investigate the reasons behind sleep and how it enhances cognitive performance by altering synaptic connections.
2. Identify and address synaptic deficits observed in neurodevelopmental conditions like Fragile X syndrome, Autism, neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and age-related synaptic changes.
3. Study genes and processes essential for neuronal regeneration to repair damaged brain tissue, including the retina.
4. Enhance knowledge of gene regulation mechanisms and explore the impact of non-coding Single Nucleotide Polymorphisms (SNPs) on causing human diseases.

The LSRP 1 will test the impact of sleep disruptions and sleep interventions on autophagosomal activity and cellular redox homeostasis mechanisms. The LSRP will perform CRISPR/Cas9 editing of genes involved in lysosomal and phagosome activity. They will perform molecular analysis of the generated mutations and biochemical phenotyping.

DESIRED QUALIFICATIONS:

• Bachelor’s degree in Molecular Biology, Biochemisty or related field or MSc desired
• Prior experience performing biology/gene editing, biochemistry related to oxidative stress, and animal biology.

Responsibilities

Core Duties:

• Plan approach to experiments in support of research projects in lab and/or field based on knowledge of scientific theory.

• Independently conduct experiments; maintain detailed records of experiments and outcomes.

• Apply the theories and methods of a life science discipline to interpret and perform analyses of experiment results; offer suggestions regarding modifications to procedures and protocols in collaboration with senior researcher.

• Review literature on an ongoing basis to remain current with new procedures and apply learnings to related research.

• Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.

• Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed.

• Assist with orientation and training of new staff or students on lab procedures or techniques.

Minimum Education and Experience

Bachelor's degree in related scientific field.

Knowledge, Skills and Abilities:

• General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.

• Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.

• Ability to maintain detailed records of experiments and outcomes.

• General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.

• Ability to work under deadlines with general guidance.

• Excellent organizational skills and demonstrated ability to accurately complete detailed work.